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T4017 |
Relebactam
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MK-7655 |
Antibacterial
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Relebactam (MK-7655) is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases. |
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T83680 |
Azurin (50-77) (P. aeruginosa) TFA
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Azurin p28,p28 |
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Azurin (50-77) is a peptide fragment derived from the copper-containing bacterial protein azurin, present in P. aeruginosa. It exhibits properties that regulate the cell cycle, inhibit cancer proliferation, and manage an... |
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T19794 |
Temafloxacin
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Omniflox |
Antibiotic
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Temafloxacin (Omniflox) is an antibiotic and antimycobacterial agent. It used to treat lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections. |
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T6179 |
Moxalactam sodium salt
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Latamoxef sodium,6059 S,Moxalactam Disodium,LY-127935,Antibiotic 6059S,Shiomarin,FestamoxinLy |
Antibacterial
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Antibiotic
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Moxalactam sodium salt (LY-127935) is an antibiotic compound more effective against Escherichia coli and Pseudomonas aeruginosathan cephalosporins. |
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T8533 |
ML318
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Others
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Antibiotic
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ML318 is a biaryl nitrile PvdQ acylase inhibitor (IC50 of 20 nM for binding in the acyl-binding site). ML318 inhibits P. aeruginosa (PAO1) with IC50 of 19 μM. ML318 prevents pyoverdine production and limits the growth of... |
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TP1663L |
CysHHC10 acetate
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CysHHC10 acetate(1408311-03-4 free base) |
Antibacterial
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CysHHC10 acetate shows antibacterial activities against both Gram-positive and Gram-negative bacteria with MIC of 10.1, 20.2, 2.5, and 1.3 mM for E. coli, P. aeruginosa, S. aureus, and S. epidermidis, respectively. |
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T41275 |
PF-04753299
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Others
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PF-04753299 is a potent and selective inhibitor of UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC), demonstrating bactericidal effects against gonococcal isolates. It exhibits inhibitory activity aga... |
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T13395L |
Zidebactam
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WCK-5107 |
Antibacterial
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Zidebactam (WCK-5107) is an effective β-lactamase inhibitor. Zidebactam also is a penicillin-binding protein2 inhibitor (IC50: 0.26 μg/mL). |
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T14043 |
4-(tert-Butyl)-benzhydroxamic Acid
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Others
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4-(tert-Butyl)-benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginosa, respectively, and it reduces the production of the virulence factor pyocyanin in P. aeruginosa with... |
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T14492 |
BAL-30072
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Others
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BAL30072 shows MIC90 values of 4 μg/mL for MDR Acinetobacter spp. and 8 μg/mL for MDR P. aeruginosa, respectively[1][2]. BAL-30072, a siderophore sulfactam, is a monocyclic beta-lactam antibiotic, with activity against m... |
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T62773 |
OX11
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OX11 is a selective inhibitor of S. pneumoniae, P. aeruginosa and E. coli bacteria. |
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T80285 |
KAMP-19
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KAMP-19 is a keratin-derived antimicrobial peptide with activity against P. aeruginosa. [1] |
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T37731 |
TPU-0037A
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TPU-0037A is an antibiotic and a congener of lydicamycin . It inhibits the growth of Gram-positive bacteria, including methicillin-resistant S. aureus (MRSA), B. subtilis, and M. luteus (MICs = 1.56-12.5 μg/ml), but not ... |
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T38334 |
Corynecin III
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Corynecin III is a chloramphenicol-like antibiotic originally isolated from Corynebacterium. It inhibits the growth of Gram-positive and Gram-negative bacteria, including S. faecalis, S. aureus, B. subtilis, E. coli, P. ... |
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T38824 |
GT-1
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LCB10-0200,GT-1 |
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GT-1 (LCB10-0200) is a siderophore-linked cephalosporin compound that effectively combats clinical isolates of various bacterial species, including P. aeruginosa, Klebsiella oxytoca, Proteus spp., Serratia marcescens, an... |
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T64012 |
DNA gyrase B-IN-1
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DNA gyrase B-IN-1 is a potent inhibitor of DNA gyrase B, exhibiting good binding affinity and stability. DNA gyrase B-IN-1 inhibits P. aeruginosa/i> DNA gyrase B (IC50: 2.2 μM). |
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T61484 |
LasR-IN-1
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LasR-IN-1 (compound 9g) is a highly effective inhibitor of LasR, exhibiting strong potency against E. coli. It also demonstrates significant anti-bacterial properties, displaying a minimum inhibitory concentration (MIC) ... |
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T60249 |
RhlR antagonist 1
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RhlR antagonist 1 is a highly effective antagonist of the RhlR protein, showing an IC50 value of 26 μM. It exhibits selective antagonistic activity against RhlR, with minimal effect on LasR and PqsR. RhlR antagonist 1 st... |
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T37464 |
CAY10711
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CAY10711 is a substituted diamine that produces rapid bactericidal activity against both Gram-positive and Gram-negative bacteria, including methicillin-resistant S. aureus (MRSA) and stationary-phase bacteria. It displa... |
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T62740 |
Antibacterial agent 110
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Antibacterial agent 110 (Compound 4e) is a potent antibacterial agent that acts on P. aeruginosa (MIC: 1 μg/ml). Antibacterial agent 110 disrupts cell membranes and has good antibacterial membrane action. |
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T80281 |
Melimine
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Parasite
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Melimine, a hybrid antimicrobial peptide derived from Melittin and Protamine, exhibits broad-spectrum activity against various microorganisms, including bacteria (P. aeruginosa, S. aureus), fungi, and protozoa [1] [2]. |
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T39790 |
LpxC-IN-5
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LpxC-IN-5 is a potent, non-hydroxamate inhibitor of LpxC, which is an enzyme known as UDP-3-O-acyl-N-acetylglucosamine deacetylase. It exhibits an IC50 value of 20 nM. Furthermore, LpxC-IN-5 displays antibacterial activi... |
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T80275 |
Lynronne-2
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Lynronne-2, an antimicrobial peptide, exhibits activity against Gram-positive bacteria, including methicillin-resistant MRSA strains (MIC: 32-256 μg/mL), and demonstrates effectiveness in combating P. aeruginosa infectio... |
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T80284 |
LMW peptide
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LMW peptide, an antimicrobial peptide, exhibits activity against both Gram-positive and Gram-negative bacteria, including B. subtilis, L. monocytogenes, E. coli, P. aeruginosa, and V. cholera [1]. |
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T60770 |
PqsR/LasR-IN-3
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PqsR/LasR-IN-3 (Compound 7a) inhibits hERG with the IC 50 of 109.01 μM which is also a PqsR and LasR systems inhibitor in P. aeruginosa [1]. |
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T76755 |
Panobacumab
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Panobacumab (KBPA101) is a fully human IgM/κ monoclonal antibody developed through the immortalization of human B lymphocytes targeted against the LPS O polysaccharide of P. aeruginosa serotype O11 [1]. |
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T82281 |
Gly-Gly-AMC
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Gly-Gly-AMC, a fluorogenic peptide substrate, facilitates the evaluation of bacterial protease activity in P. aeruginosa and S. aureus [1] [2]. |
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T80371 |
Distinctin
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Distinctin, an antimicrobial peptide derived from frog skin, exhibits antibacterial activity against a range of pathogens including E. faecalis, P. aeruginosa, S. aureus, and E. coli, with minimum inhibitory concentratio... |
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T80526 |
L-K6L9
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L-K6L9 exhibits antimicrobial and antibiofilm properties effective against P. aeruginosa associated with cystic fibrosis, demonstrating both stability and resistance to degradation by sputum proteases from cystic fibrosi... |
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T70386 |
QZN34
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QZN34 is a PqsR inhibitor which prevents S. aureus biofilm formation, severely damaged established S. aureus biofilms, and perturbed P. aeruginosa biofilm development. The mechanism of action of QZN 34 toward Gram-positi... |
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T83847 |
SP-A (196-215) (human) TFA
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Surfactant Protein A,SPA4 |
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Surfactant protein A (SP-A) (196-215) is a synthetic peptide derived from the C-terminal carbohydrate recognition domain of human SP-A, specifically amino acids 196-215. This peptide suppresses LPS-induced TNF-α release ... |
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T80091 |
Ranalexin
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Ranalexin, an antimicrobial peptide, demonstrates inhibition of S. aureus, E. coli, and P. aeruginosa, with respective minimum inhibitory concentrations (MICs) of 4, 32, and 128 μg/mL [1]. |
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T71011 |
Perfluorinated SAHA
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Perfluorinated SAHA is an HDAC inhibitor for use in cancer treatment regimens, with demonstrated greater antiproliferative properties than SAHA . PFSAHA has also been shown to have higher selectivity for PA3774, an HDAC-... |
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T37730 |
Saccharocarcin A
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Saccharocarcin A is an antibiotic originally isolated from S. aerocolonigenes subsp. antibiotica. It is active against M. luteus, S. aureus, E. coli, P. aeruginosa, and C. albicans in a disc assay. Saccharocarcin A inhib... |
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T61067 |
MurB-IN-1
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MurB-IN-1 (compound 44) is a potent inhibitor of MurB, an essential enzyme involved in the synthesis of bacterial cell wall. With a binding affinity of K d 3.57 μM, MurB-IN-1 effectively hinders the activity of MurB, pre... |
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T61126 |
Antibacterial synergist 1
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Antibacterial synergist 1 (compound 20P) is a potent inhibitor of bacterial biofilm formation. It effectively suppresses the production of pyocyanin, with an IC 50 of 8.6 μM, and inhibits biofilm formation with an IC 50 ... |
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T80139 |
CRAMP-18 (mouse)
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Antibiotic
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CRAMP-18 (mouse) is an antibiotic peptide with demonstrated efficacy against Gram-negative bacteria, including S. typhimurium and P. aeruginosa, while exhibiting no hemolytic activity. This compound shows promise for res... |
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T62015 |
PqsR/LasR-IN-1
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PqsR/LasR-IN-1 (Compound 2a) is a potent inhibitor of LasR and PqsR systems in P. aeruginosa. PqsR/LasR-IN-1 is also a inhibitor of hERG (IC50= 6.77 μM). |
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T76226 |
C[Arg-Arg-Arg-Arg-Nal-Nal-Nal]
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Compound 9C [c[Arg-Arg-Arg-Arg-Nal-Nal-Nal]] demonstrates broad-spectrum efficacy against drug-resistant Gram-positive and Gram-negative bacteria. It exhibits minimum inhibitory concentrations (MICs) of 3.1 μg/mL for MRS... |
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T37039 |
Betulinic Aldehyde oxime
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Betulinic aldehyde oxime is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin .1It is active againstE. aerogenes,E. coli,E. faecalis,P. aeruginosa,S. aureus, andC. albicans, as w... |
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T80274 |
Lynronne-1
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Lynronne-1, an antimicrobial peptide, exhibits activity against Gram-positive bacteria, including multi-drug resistant (MDR) strains, with a minimal inhibitory concentration (MIC) of 8-32 μg/mL for methicillin-resistant ... |
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T83717 |
Cys-Pexiganan TFA
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Cys-pexiganan, a derivative of pexiganan with an added N-terminal cysteine, is an antimicrobial peptide effective against P. aeruginosa and S. aureus, with minimum inhibitory concentrations (MICs) of 64 and 16 µg/ml, res... |
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T63252 |
Antibacterial agent 113
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Antibacterial agent 113 was an effective antimicrobial agent (antibacterial) against P. aeruginosa, S. mutans, B. subtilis, E. coli, E. faecalis, S. typhimuriumand and S. aureus microorganisms exhibited antibacterial eff... |
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T78673 |
Antibacterial agent 135
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Antibacterial Agent 135 (example 7) effectively inhibits various bacteria, including P. aeruginosa, A. baumannii, E. coli, and K. pneumoniae, with a minimum inhibitory concentration (MIC) greater than 64 μg/mL [1]. |
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T75172 |
Antibacterial agent 143
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Compound 5a (Antibacterial agent 143) is an antibacterial agent exhibiting minimum inhibitory concentrations (MICs) of 25 μg/mL against B. subtilis ATCC6633 and S. aureus ATCC6538, and 50 μg/mL against P. aeruginosa ATCC... |
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T80307 |
Dermaseptin-B3
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Dermaseptin-B3 is an antimicrobial peptide that exhibits inhibitory effects against both Gram-positive and Gram-negative bacterial strains, with minimum inhibitory concentrations (MICs) of 1.3, 2.3, 5.0, 2.6, and 2.3 μM ... |
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T75996 |
Murepavadin TFA
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Murepavadin (POL7080) (TFA), a 14-amino-acid cyclic peptide, serves as a highly potent, specific antibiotic with remarkable antimicrobial activity against P. aeruginosa, demonstrated by MIC 50 and MIC 90 values of 0.12 m... |
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T37282 |
1-Palmitoyl Lysophosphatidic Acid
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Antibacterial
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1-Palmitoyl Lysophosphatidic Acid is an analog of LPA and improves the the action of ampicillin, piperacillin, and ceftazidime on various strains of P. aeruginosa via binding both Ca2+ and Mg2+. |
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T83738 |
SMAP 29 (ovine) TFA
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Sheep Myeloid Antimicrobial Peptide 29 |
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SMAP 29, a bactericidal antimicrobial peptide and a cleavage product from the C-terminus of an ovine cathelicidin prepropeptide, is effective against P. aeruginosa strain PAO1 in both low- and high-salt conditions, as de... |
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T36598 |
Enopeptin A
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Enopeptin A, originally isolated from a culture broth of Streptomyces sp. RK-1051, is a depsipeptide antibiotic that contains two unusual amino acids (N-methylalanine and 4-methylproline) and features a pentaenone side c... |
